category	go_number	go_term	definition
extracellular off-reactions	GO:1990034	calcium ion export from cell	The directed movement of calcium ions out of a cell.
on-off-reactions at unspecified site	GO:1903169	regulation of calcium ion transmembrane transport	Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport.
on-off-reactions at unspecified site	GO:1903170	negative regulation of calcium ion transmembrane transport	Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport.
off-reactions at unspecified site	GO:1901021	positive regulation of calcium ion transmembrane transporter activity	Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transporter activity.
extracellular on-reactions	GO:0036128	CatSper complex	A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits.
extracellular on-reactions	GO:0098703	calcium ion import across plasma membrane	The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol.
extracellular on-reactions	GO:1902606	regulation of large conductance calcium-activated potassium channel activity	Any process that modulates the frequency, rate or extent of large conductance calcium-activated potassium channel activity.
extracellular on-reactions	GO:1902608	positive regulation of large conductance calcium-activated potassium channel activity	Any process that activates or increases the frequency, rate or extent of large conductance calcium-activated potassium channel activity.
extracellular on-reactions	GO:1990035	calcium ion import into cell	The directed movement of calcium ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.
intracellular off-reactions	GO:0032470	positive regulation of endoplasmic reticulum calcium ion concentration	Any process that increases the concentration of calcium ions in the endoplasmic reticulum.
intracellular off-reactions	GO:0032865	ERMES complex	A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. The complex is also associated with actively replicating mitochondrial DNA nucleoids, and may further coordinate mitochondrial genome replication and membrane growth.
intracellular off-reactions	GO:0036444	calcium ion transmembrane import into mitochondrion	A process in which a calcium ion (Ca2+) is transported from one side of a membrane to the other into the mitochondrion by means of some agent such as a transporter or pore.
intracellular off-reactions	GO:0044233	ER-mitochondrion membrane contact site	A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange.
intracellular off-reactions	GO:0051208	sequestering of calcium ion	The process of binding or confining calcium ions such that they are separated from other components of a biological system.
intracellular off-reactions	GO:0051282	regulation of sequestering of calcium ion	Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.
intracellular off-reactions	GO:0051283	negative regulation of sequestering of calcium ion	Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.
intracellular off-reactions	GO:0051284	positive regulation of sequestering of calcium ion	Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.
intracellular off-reactions	GO:0051561	positive regulation of mitochondrial calcium ion concentration	Any process that increases the concentration of calcium ions in mitochondria.
intracellular off-reactions	GO:0051561	positive regulation of mitochondrial calcium ion concentration	Any process that increases the concentration of calcium ions in mitochondria.
intracellular off-reactions	GO:0051564	positive regulation of smooth endoplasmic reticulum calcium ion concentration	Any process that increases the concentration of calcium ions in the smooth endoplasmic reticulum.
intracellular off-reactions	GO:1902080	regulation of calcium ion import into sarcoplasmic reticulum	Any process that modulates the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum.
intracellular off-reactions	GO:1902081	negative regulation of calcium ion import into sarcoplasmic reticulum	Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum.
intracellular off-reactions	GO:1902082	positive regulation of calcium ion import into sarcoplasmic reticulum	Any process that activates or increases the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum.
intracellular off-reactions	GO:1903515	calcium ion transport from cytosol to endoplasmic reticulum	The directed movement of calcium ion from cytosol to endoplasmic reticulum.
intracellular off-reactions	GO:1990036	calcium ion import into sarcoplasmic reticulum	The directed movement of calcium ions into a sarcoplasmic reticulum.
intracellular off-reactions	GO:1990246	uniplex complex	A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.
intracellular off-reactions	GO:1990629	phospholamban complex	A protein complex found as a homopentamer of the phospholamban (PLN) protein in the sarcoplasmic reticulum (SR) membrane of cardiomyocytes. Cardiac PLN is a main determinant of muscle contraction and relaxation, by regulating intracellular calcium levels.
intracellular on-off-reactions	GO:0006851	mitochondrial calcium ion transport	The directed movement of calcium ions (Ca2+) into, out of or within a mitochondrion.
intracellular on-off-reactions	GO:0032468	Golgi calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings.
intracellular on-off-reactions	GO:0032469	endoplasmic reticulum calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings.
intracellular on-off-reactions	GO:0032472	Golgi calcium ion transport	The directed movement of calcium ions (Ca2+) into, out of or within the Golgi apparatus.
intracellular on-off-reactions	GO:0051560	mitochondrial calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.
intracellular on-off-reactions	GO:0051560	mitochondrial calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.
intracellular on-off-reactions	GO:0051563	smooth endoplasmic reticulum calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions within the smooth endoplasmic reticulum of a cell or between the smooth endoplasmic reticulum and its surroundings.
intracellular on-off-reactions	GO:0070296	sarcoplasmic reticulum calcium ion transport	The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum.
intracellular on-reactions	GO:0001639	PLC activating G-protein coupled glutamate receptor activity	A G-protein coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system.
intracellular on-reactions	GO:0002115	store-operated calcium entry	A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.
intracellular on-reactions	GO:0005218	intracellular ligand-gated calcium channel activity	Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts.
intracellular on-reactions	GO:0005219	ryanodine-sensitive calcium-release channel activity	Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
intracellular on-reactions	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts.
intracellular on-reactions	GO:0007223	Wnt signaling pathway, calcium modulating pathway	The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).
intracellular on-reactions	GO:0008377	light-induced release of internally sequestered calcium ion	The process in which the detection of light triggers the release of internally sequestered calcium ions.
intracellular on-reactions	GO:0008591	regulation of Wnt signaling pathway, calcium modulating pathway	Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).
intracellular on-reactions	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
intracellular on-reactions	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
intracellular on-reactions	GO:0015278	calcium-release channel activity	Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
intracellular on-reactions	GO:0015279	store-operated calcium channel activity	A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.
intracellular on-reactions	GO:0031585	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
intracellular on-reactions	GO:0031586	negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
intracellular on-reactions	GO:0031587	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
intracellular on-reactions	GO:0032237	activation of store-operated calcium channel activity	A process that initiates the activity of an inactive store-operated calcium channel.
intracellular on-reactions	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration	Any process that decreases the concentration of calcium ions in the endoplasmic reticulum.
intracellular on-reactions	GO:0045812	negative regulation of Wnt signaling pathway, calcium modulating pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).
intracellular on-reactions	GO:0045813	positive regulation of Wnt signaling pathway, calcium modulating pathway	Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).
intracellular on-reactions	GO:0048763	calcium-induced calcium release activity	Release of calcium ions from an intracellular vesicle on induction by increased calcium concentration.
intracellular on-reactions	GO:0051209	release of sequestered calcium ion into cytosol	The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.
intracellular on-reactions	GO:0051279	regulation of release of sequestered calcium ion into cytosol	Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
intracellular on-reactions	GO:0051280	negative regulation of release of sequestered calcium ion into cytosol	Any process that stops, prevents, or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
intracellular on-reactions	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
intracellular on-reactions	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G-protein coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol.
intracellular on-reactions	GO:0051562	negative regulation of mitochondrial calcium ion concentration	Any process that decreases the concentration of calcium ions in mitochondria.
intracellular on-reactions	GO:0051565	negative regulation of smooth endoplasmic reticulum calcium ion concentration	Any process that decreases the concentration of calcium ions in the smooth endoplasmic reticulum.
intracellular on-reactions	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
intracellular on-reactions	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
intracellular on-reactions	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity	Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
intracellular on-reactions	GO:0061454	Golgi calcium ion export	The directed movement of calcium ions (Ca2+) out of the Golgi apparatus into the cytosol.
intracellular on-reactions	GO:0072345	NAADP-sensitive calcium-release channel activity	Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts.
intracellular on-reactions	GO:0072346	cADPR-sensitive calcium-release channel activity	Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when cyclic adenosine diphosphate ribose (cADPR) has been bound by the channel complex or one of its constituent parts.
intracellular on-reactions	GO:0086094	positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction	An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of cardiac muscle contraction through phosphorylation and enhancement of the ryanodine receptor, a calcium-activated calcium-release channel found in the membrane of the sarcoplasmic reticulum. An adrenergic receptor-activated adenylate cyclase generates cAMP. cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the ryanodine receptor (RyR). PKA-phosphorylation of RyR enhances channel activity by sensitizing the channel to cytosolic calcium. Cytosolic calcium stimulates contractile proteins to promote muscle contraction.
intracellular on-reactions	GO:1901339	regulation of store-operated calcium channel activity	Any process that modulates the frequency, rate or extent of store-operated calcium channel activity.
intracellular on-reactions	GO:1901340	negative regulation of store-operated calcium channel activity	Any process that stops, prevents or reduces the frequency, rate or extent of store-operated calcium channel activity.
intracellular on-reactions	GO:1901341	positive regulation of store-operated calcium channel activity	Any process that activates or increases the frequency, rate or extent of store-operated calcium channel activity.
intracellular on-reactions	GO:1901472	regulation of Golgi calcium ion export	Any process that modulates the frequency, rate or extent of Golgi calcium ion export.
intracellular on-reactions	GO:1903514	calcium ion transport from endoplasmic reticulum to cytosol	The directed movement of calcium ion from endoplasmic reticulum to cytosol.
intracellular on-reactions	GO:1990425	ryanodine receptor complex	A voltage-gated calcium-release channel complex of the sarcoplasmic or endoplasmic reticulum. It plays an important role in the excitation-contraction (E-C) coupling of muscle cells. RyR comprises a family of ryanodine receptors, widely expressed throughout the animal kingdom.
intracellular on-reactions	GO:2001256	regulation of store-operated calcium entry	Any process that modulates the frequency, rate or extent of store-operated calcium entry.
off-reactions at unspecified site	GO:0005388	calcium-transporting ATPase activity	Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans).
off-reactions at unspecified site	GO:0005432	calcium:sodium antiporter activity	Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in).
off-reactions at unspecified site	GO:0008273	calcium, potassium:sodium antiporter activity	Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).
off-reactions at unspecified site	GO:0015368	calcium:cation antiporter activity	Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in).
off-reactions at unspecified site	GO:0015369	calcium:proton antiporter activity	Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in).
off-reactions at unspecified site	GO:0051481	negative regulation of cytosolic calcium ion concentration	Any process that decreases the concentration of calcium ions in the cytosol.
off-reactions at unspecified site	GO:0086038	calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential	Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell.
off-reactions at unspecified site	GO:0086039	calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential	Catalysis of the transfer of a solute or solutes from one side of a cardiac muscle cell plasma membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). The transfer contributes to the regulation of the plasma membrane potential.
off-reactions at unspecified site	GO:0090534	calcium ion-transporting ATPase complex	Protein complex that carries out the reaction: ATP + H2O + Ca2+(out) = ADP + phosphate + Ca2+(in).
off-reactions at unspecified site	GO:1901019	regulation of calcium ion transmembrane transporter activity	Any process that modulates the frequency, rate or extent of calcium ion transmembrane transporter activity.
off-reactions at unspecified site	GO:1901020	negative regulation of calcium ion transmembrane transporter activity	Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transporter activity.
off-reactions at unspecified site	GO:1901021	positive regulation of calcium ion transmembrane transporter activity	Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transporter activity.
off-reactions at unspecified site	GO:1901894	regulation of calcium-transporting ATPase activity	Any process that modulates the frequency, rate or extent of calcium-transporting ATPase activity.
off-reactions at unspecified site	GO:1901895	negative regulation of calcium-transporting ATPase activity	Any process that stops, prevents or reduces the frequency, rate or extent of calcium-transporting ATPase activity.
off-reactions at unspecified site	GO:1901896	positive regulation of calcium-transporting ATPase activity	Any process that activates or increases the frequency, rate or extent of calcium-transporting ATPase activity.
off-reactions at unspecified site	GO:1903279	regulation of calcium:sodium antiporter activity	Any process that modulates the frequency, rate or extent of calcium:sodium antiporter activity.
off-reactions at unspecified site	GO:1903280	negative regulation of calcium:sodium antiporter activity	Any process that stops, prevents or reduces the frequency, rate or extent of calcium:sodium antiporter activity.
off-reactions at unspecified site	GO:1903281	positive regulation of calcium:sodium antiporter activity	Any process that activates or increases the frequency, rate or extent of calcium:sodium antiporter activity.
on-off-reactions at unspecified site	GO:0006816	calcium ion transport	The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
on-off-reactions at unspecified site	GO:0006874	cellular calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
on-off-reactions at unspecified site	GO:0010617	circadian regulation of calcium ion oscillation	Any process that modulates the concentration of cytosolic free calcium ion [Ca2+]cyt with a regularity of approximately 24 hours.
on-off-reactions at unspecified site	GO:0015085	calcium ion transmembrane transporter activity	Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other.
on-off-reactions at unspecified site	GO:0034704	calcium channel complex	An ion channel complex through which calcium ions pass.
on-off-reactions at unspecified site	GO:0051480	cytosolic calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
on-off-reactions at unspecified site	GO:0051924	regulation of calcium ion transport	Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
on-off-reactions at unspecified site	GO:0051926	negative regulation of calcium ion transport	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
on-off-reactions at unspecified site	GO:0051928	positive regulation of calcium ion transport	Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
on-off-reactions at unspecified site	GO:0055074	calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell.
on-off-reactions at unspecified site	GO:0060401	cytosolic calcium ion transport	The directed movement of calcium ions (Ca2+) into, out of or within the cytosol.
on-off-reactions at unspecified site	GO:0070509	calcium ion import	The directed movement of calcium ions into a cell or organelle.
on-off-reactions at unspecified site	GO:0070588	calcium ion transmembrane transport	A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
on-off-reactions at unspecified site	GO:0090279	regulation of calcium ion import	Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
on-off-reactions at unspecified site	GO:0090280	positive regulation of calcium ion import	Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
on-off-reactions at unspecified site	GO:0090281	negative regulation of calcium ion import	Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
on-off-reactions at unspecified site	GO:1901660	calcium ion export	The directed movement of calcium ion out of a cell or organelle.
on-reactions at unspecified site	GO:0005245	voltage-gated calcium channel activity	Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
on-reactions at unspecified site	GO:0005246	calcium channel regulator activity	Modulates the activity of a calcium channel.
on-reactions at unspecified site	GO:0005262	calcium channel activity	Catalysis of facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
on-reactions at unspecified site	GO:0005891	voltage-gated calcium channel complex	A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
on-reactions at unspecified site	GO:0007204	positive regulation of cytosolic calcium ion concentration	Any process that increases the concentration of calcium ions in the cytosol.
on-reactions at unspecified site	GO:0007340	acrosome reaction	The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the egg.
on-reactions at unspecified site	GO:0008086	light-activated voltage-gated calcium channel activity	Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
on-reactions at unspecified site	GO:0008087	light-activated voltage-gated calcium channel complex	A protein complex that forms a transmembrane channel through which calcium ions may cross a cell membrane in response to changes in membrane potential generated in response to a light stimulus.
on-reactions at unspecified site	GO:0008331	high voltage-gated calcium channel activity	Catalysis of the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded.
on-reactions at unspecified site	GO:0008332	low voltage-gated calcium channel activity	Catalysis of the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded.
on-reactions at unspecified site	GO:0010522	regulation of calcium ion transport into cytosol	Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.
on-reactions at unspecified site	GO:0010523	negative regulation of calcium ion transport into cytosol	Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.
on-reactions at unspecified site	GO:0010524	positive regulation of calcium ion transport into cytosol	Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.
on-reactions at unspecified site	GO:0015275	stretch-activated, cation-selective, calcium channel activity	Catalysis of the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching.
on-reactions at unspecified site	GO:0019855	calcium channel inhibitor activity	Stops, prevents, or reduces the activity of a calcium channel.
on-reactions at unspecified site	GO:0060072	large conductance calcium-activated potassium channel activity	Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
on-reactions at unspecified site	GO:0060402	calcium ion transport into cytosol	The directed movement of calcium ions (Ca2+) into the cytosol.
on-reactions at unspecified site	GO:0060470	positive regulation of cytosolic calcium ion concentration involved in egg activation	The process that increases the concentration of calcium ions in the cytosol after fertilization or the physiological activation of an egg.
on-reactions at unspecified site	GO:0061577	generation of L-type calcium current	A process in which a calcium ion is transported from one side of a membrane to the other by means of an L-type calcium channel.
on-reactions at unspecified site	GO:0070978	voltage-gated calcium channel complex assembly	Cellular protein complex assembly that results in the formation of a voltage-gated calcium channel complex.
on-reactions at unspecified site	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
on-reactions at unspecified site	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential	Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
on-reactions at unspecified site	GO:0086057	voltage-gated calcium channel activity involved in bundle of His cell action potential	Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a bundle of His cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
on-reactions at unspecified site	GO:0086058	voltage-gated calcium channel activity involved in Purkinje myocyte cell action potential	Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an Purkinje myocyte cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
on-reactions at unspecified site	GO:0086059	voltage-gated calcium channel activity involved SA node cell action potential	Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
on-reactions at unspecified site	GO:0097364	stretch-activated, cation-selective, calcium channel activity involved in regulation of action potential	Catalysis of the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential.
on-reactions at unspecified site	GO:0097365	stretch-activated, cation-selective, calcium channel activity involved in regulation of cardiac muscle cell action potential	Catalysis of the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential in a cardiac muscle cell.
on-reactions at unspecified site	GO:0097553	calcium ion transmembrane import into cytosol	A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore.
on-reactions at unspecified site	GO:1901385	regulation of voltage-gated calcium channel activity	Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity.
on-reactions at unspecified site	GO:1901386	negative regulation of voltage-gated calcium channel activity	Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated calcium channel activity.
on-reactions at unspecified site	GO:1901387	positive regulation of voltage-gated calcium channel activity	Any process that activates or increases the frequency, rate or extent of voltage-gated calcium channel activity.
on-reactions at unspecified site	GO:1901841	regulation of high voltage-gated calcium channel activity	Any process that modulates the frequency, rate or extent of high voltage-gated calcium channel activity.
on-reactions at unspecified site	GO:1901843	positive regulation of high voltage-gated calcium channel activity	Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity.
on-reactions at unspecified site	GO:1902225	negative regulation of acrosome reaction	Any process that stops, prevents or reduces the frequency, rate or extent of acrosome reaction.
on-reactions at unspecified site	GO:1902514	regulation of generation of L-type calcium current	Any process that modulates the frequency, rate or extent of generation of L-type calcium current.
on-reactions at unspecified site	GO:1902607	negative regulation of large conductance calcium-activated potassium channel activity	Any process that stops, prevents or reduces the frequency, rate or extent of large conductance calcium-activated potassium channel activity.
on-reactions at unspecified site	GO:1902656	calcium ion import into cytosol	The directed movement of calcium ion into a cytosol.
on-reactions at unspecified site	GO:1990028	intermediate voltage-gated calcium channel activity	Catalysis of the transmembrane transfer of a calcium ion by an intermediate voltage-gated channel. An intermediate voltage-gated channel is a channel whose open state is dependent on intermediate voltage across the membrane in which it is embedded.
on-reactions at unspecified site	GO:1990454	L-type voltage-gated calcium channel complex	A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation.
on-reactions at unspecified site	GO:2000344	positive regulation of acrosome reaction	Any process that activates or increases the frequency, rate or extent of the acrosome reaction.
signaling functions	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity	Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin.
signaling functions	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
signaling functions	GO:0004683	calmodulin-dependent protein kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin.
signaling functions	GO:0004698	calcium-dependent protein kinase C activity	Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol and calcium.
signaling functions	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions.
signaling functions	GO:0005227	calcium activated cation channel activity	Catalysis of the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient.
signaling functions	GO:0005229	intracellular calcium activated chloride channel activity	Catalysis of the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
signaling functions	GO:0005509	calcium ion binding	Interacting selectively and non-covalently with calcium ions (Ca2+).
signaling functions	GO:0005513	detection of calcium ion	The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal.
signaling functions	GO:0005516	calmodulin binding	Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
signaling functions	GO:0005544	calcium-dependent phospholipid binding	Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
signaling functions	GO:0005954	calcium- and calmodulin-dependent protein kinase complex	An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins.
signaling functions	GO:0005955	calcineurin complex	A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin.
signaling functions	GO:0008048	calcium sensitive guanylate cyclase activator activity	Increases the activity of guanylate cyclase in response to a change in calcium ion concentration.
signaling functions	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin.
signaling functions	GO:0008427	calcium-dependent protein kinase inhibitor activity	Stops, prevents or reduces the activity of a calcium-dependent protein kinase.
signaling functions	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity	Modulation of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase.
signaling functions	GO:0009931	calcium-dependent protein serine/threonine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions are dependent on the presence of calcium ions.
signaling functions	GO:0010857	calcium-dependent protein kinase activity	Catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the presence of calcium.
signaling functions	GO:0010858	calcium-dependent protein kinase regulator activity	Modulates the activity of a calcium-dependent protein kinase, an enzyme which phosphorylates a protein in a calcium-dependent manner.
signaling functions	GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity	Stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner.
signaling functions	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.
signaling functions	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction.
signaling functions	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling	Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing the calcium ion signals that trigger contraction.
signaling functions	GO:0014723	regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril	Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing calcium ion binding affinity of the myofibril.
signaling functions	GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion	Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.
signaling functions	GO:0014810	positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion	Any process that activates, maintains or increases the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.
signaling functions	GO:0014811	negative regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion	Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.
signaling functions	GO:0015269	calcium-activated potassium channel activity	Catalysis of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient.
signaling functions	GO:0016286	small conductance calcium-activated potassium channel activity	Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
signaling functions	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
signaling functions	GO:0016340	calcium-dependent cell-matrix adhesion	The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction.
signaling functions	GO:0017156	calcium ion-dependent exocytosis	The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, requiring the presence of calcium ions.
signaling functions	GO:0017158	regulation of calcium ion-dependent exocytosis	Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis.
signaling functions	GO:0018025	calmodulin-lysine N-methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine.
signaling functions	GO:0019722	calcium-mediated signaling	Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
signaling functions	GO:0021808	cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration	The process that results in the fluctuations in intracellular calcium that are responsible for the initiation of movement as a component of the process of cerebral cortex glial-mediated radial migration.
signaling functions	GO:0021845	neurotransmitter-mediated guidance of interneurons involved in substrate-independent cerebral cortex tangential migration	The response of migrating interneurons to neurotransmitters that alter electrical activity in cells in calcium dependent manner.
signaling functions	GO:0021945	positive regulation of cerebellar granule cell migration by calcium	The process that increases the extent of granule cell motility using intracellular calcium signaling mechanisms during radial migration.
signaling functions	GO:0022894	Intermediate conductance calcium-activated potassium channel activity	Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
signaling functions	GO:0030172	troponin C binding	Interacting selectively and non-covalently with troponin C, the calcium-binding subunit of the troponin complex.
signaling functions	GO:0030899	calcium-dependent ATPase activity	Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+).
signaling functions	GO:0032517	SOD1-calcineurin complex	A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; complex formation is implicated in activation of calcineurin by SOD1.
signaling functions	GO:0032766	NHE3/E3KARP/ACTN4 complex	A heterotrimeric protein complex formed by the association of NHE3, E3KARP and alpha-actinin upon an increase in calcium ion concentration; found in clusters localized on plasma membrane and in intracellular compartments.
signaling functions	GO:0033173	calcineurin-NFAT signaling cascade	Any intracellular signal transduction in which the signal is passed on within the by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G-protein coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+).
signaling functions	GO:0033192	calmodulin-dependent protein phosphatase activity	Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin.
signaling functions	GO:0043006	activation of phospholipase A2 activity by calcium-mediated signaling	A series of molecular signals that leads to the upregulation of calcium-dependent phospholipase A2 activity in response to the signal.
signaling functions	GO:0044548	S100 protein binding	Interacting selectively and non-covalently with a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS.
signaling functions	GO:0045955	negative regulation of calcium ion-dependent exocytosis	Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis.
signaling functions	GO:0045956	positive regulation of calcium ion-dependent exocytosis	Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis.
signaling functions	GO:0046586	regulation of calcium-dependent cell-cell adhesion	Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
signaling functions	GO:0046587	positive regulation of calcium-dependent cell-cell adhesion	Any process that activates or increases the frequency, rate or extent of calcium-dependent cell-cell adhesion.
signaling functions	GO:0046588	negative regulation of calcium-dependent cell-cell adhesion	Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-dependent cell-cell adhesion.
signaling functions	GO:0047498	calcium-dependent phospholipase A2 activity	Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+.
signaling functions	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity	Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. The reaction is calmodulin and calcium-sensitive.
signaling functions	GO:0048306	calcium-dependent protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
signaling functions	GO:0048791	calcium ion-dependent exocytosis of neurotransmitter	The release of a neurotransmitter into the synaptic cleft, where the release step is dependent on the presence of calcium ions (Ca2+). The neurotransmitter is contained within a membrane-bounded vesicle, and is released by fusion of the vesicle with the presynaptic plasma membrane of a nerve cell.
signaling functions	GO:0050372	ubiquitin-calmodulin ligase activity	Catalysis of the reaction: n ATP + calmodulin + n ubiquitin = n AMP + n diphosphate + ubiquitin(n)-calmodulin.
signaling functions	GO:0050429	calcium-dependent phospholipase C activity	Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+.
signaling functions	GO:0051592	response to calcium ion	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
signaling functions	GO:0060471	cortical granule exocytosis	The process of secretion by a cell that results in the release of intracellular molecules contained within a cortical granule by fusion of the vesicle with the plasma membrane of a cell. A cortical granule is a specialized secretory vesicle that is released during egg activation that changes the surface of the egg to prevent polyspermy.
signaling functions	GO:0060472	positive regulation of cortical granule exocytosis by positive regulation of cytosolic calcium ion concentration	Any process that activates or increases the frequency, rate or extent of cortical granule exocytosis by directing movement of calcium ions (Ca2+) into the cytosol.
signaling functions	GO:0060478	acrosomal vesicle exocytosis	The release of intracellular molecules contained within the acrosomal granule by fusion of the vesicle with the plasma membrane of the oocyte, requiring calcium ions.
signaling functions	GO:0061400	positive regulation of transcription from RNA polymerase II promoter in response to calcium ion	Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a calcium ion stimulus.
signaling functions	GO:0061588	calcium activated phospholipid scrambling	The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.
signaling functions	GO:0061589	calcium activated phosphatidylserine scrambling	The movement of a population of phosphatidylserine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.
signaling functions	GO:0061590	calcium activated phosphatidylcholine scrambling	The movement of a population of phosphatidylcholine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.
signaling functions	GO:0061591	calcium activated galactosylceramide scrambling	The movement of a population of galactosylceramide molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.
signaling functions	GO:0070884	regulation of calcineurin-NFAT signaling cascade	Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
signaling functions	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
signaling functions	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade.
signaling functions	GO:0071277	cellular response to calcium ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
signaling functions	GO:0072732	cellular response to calcium ion starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of calcium ions.
signaling functions	GO:0097231	cell motility in response to calcium ion	Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a calcium ion stimulus.
signaling functions	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter	The fast, initial phase of calcium ion-induced neurotransmitter release, via exocytosis, into the synaptic cleft. This depends on low affinity calcium sensors and typically begins a fraction of a millisecond after Ca2+ influx, and decays rapidly (1-10ms) with a decay constant of around 5-10ms. The underlying molecular mechanisms of this process are distinct from those of the later, slow phase of release.
signaling functions	GO:0098747	slow, calcium ion-dependent exocytosis of neurotransmitter	The slow, second phase of calcium ion-induced neurotransmitter release, via exocytosis, into the synaptic cleft. This depends on high affinity calcium sensors and decays slowly, typically with a decay constant of over 100ms. The underlying molecular mechanisms of this process are distinct from those of the earlier, fast phase of release.
signaling functions	GO:1900621	regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling	Calcium-mediated signaling that results in regulation of transcription from an RNA polymerase II promoter.
signaling functions	GO:1900622	positive regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling	Calcium-mediated signaling that results in positive regulation of transcription from an RNA polymerase II promoter.
signaling functions	GO:1901197	positive regulation of calcium-mediated signaling involved in cellular response to calcium ion	Any positive regulation of calcium-mediated signaling that is involved in cellular response to calcium ion.
signaling functions	GO:1901876	regulation of calcium ion binding	Any process that modulates the frequency, rate or extent of calcium ion binding.
signaling functions	GO:1901877	negative regulation of calcium ion binding	Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion binding.
signaling functions	GO:1901878	positive regulation of calcium ion binding	Any process that activates or increases the frequency, rate or extent of calcium ion binding.
signaling functions	GO:1902938	regulation of intracellular calcium activated chloride channel activity	Any process that modulates the frequency, rate or extent of intracellular calcium activated chloride channel activity.
signaling functions	GO:1902939	negative regulation of intracellular calcium activated chloride channel activity	Any process that stops, prevents or reduces the frequency, rate or extent of intracellular calcium activated chloride channel activity.
signaling functions	GO:1902940	positive regulation of intracellular calcium activated chloride channel activity	Any process that activates or increases the frequency, rate or extent of intracellular calcium activated chloride channel activity.
signaling functions	GO:1903233	regulation of calcium ion-dependent exocytosis of neurotransmitter	Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter.
signaling functions	GO:1903234	negative regulation of calcium ion-dependent exocytosis of neurotransmitter	Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter.
signaling functions	GO:1903235	positive regulation of calcium ion-dependent exocytosis of neurotransmitter	Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter.
signaling functions	GO:1903610	regulation of calcium-dependent ATPase activity	Any process that modulates the frequency, rate or extent of calcium-dependent ATPase activity.
signaling functions	GO:1903611	negative regulation of calcium-dependent ATPase activity	Any process that stops, prevents or reduces the frequency, rate or extent of calcium-dependent ATPase activity.
signaling functions	GO:1903612	positive regulation of calcium-dependent ATPase activity	Any process that activates or increases the frequency, rate or extent of calcium-dependent ATPase activity.
signaling functions	GO:1990092	calcium-dependent self proteolysis	The sodium-dependent hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds.
signaling functions	GO:1990504	dense core granule exocytosis	The release of intracellular molecules (e.g. neuropeptides, insulin-related peptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell, requiring the presence of calcium ions.